Selective toxicity against microbes means killing the microbial cells but not the host's cells antibiotics are antimicrobial agents which were originally defined as the substances produced by microorganisms that inhibit other microorganisms. Both preclinical in vitro and in vivo studies as well as phase i clinical trials suggest a cell-intrinsic mechanism of selective toxicity of cancer cells as compared to normal cells however, the mechanism(s) for cancer cell-selective toxicity remain unknown. Radio-chemotherapy d o 2, and h 2o 2 increase labile iron causing cancer cell-selective ascorbate toxicity d therapeutic levels of ascorbate are achievable and well. Start studying microbiology ch 10 learn vocabulary, terms, and more with flashcards, games, and other study tools selective toxicity uses-chemotherapy .
Selective toxicity-- chemotherapy 2 chemistry, pharmaceutical 3 drugs--physiological effect i title 615'7 rm262 library of congress cataloging in publication data. Because of this, acyclovir has a particularly high degree of selective toxicity, and serious side effects are less common with acyclovir than with most other nucleoside analogues used in antiviral chemotherapy. Cancer chemotherapy is a major component of cancer therapy, heidelberger et al were the first to practically show the concept of “selective toxicity . Section reference 1: section 131 antimicrobial chemotherapy 5) selective toxicity: difficulty: easy learning objective 1: lo 132 report mechanisms of action by which antimicrobial agents may work, possible ways in which they may exert toxic side effects, and ways in which drug resistance may develop.
Selective toxicity refers to the ability of the drug to targets sites that are relative specific to the microorganism responsible for infection sometimes these sites are unique to the microorganism or simply more essential to survival of the microorganism than to the host. Selective toxicity, an essential requirement for successful chemotherapy selective toxicity, an essential requirement for successful chemotherapy t s work. Remember that selective toxicity is the specific inhibition of some types of cells but not others in the case of antimicrobial drugs, we want the drug to be selectively toxic for whatever . Request pdf on researchgate | selective and nonselective toxicity of trail/apo2l combined with chemotherapy in human bone tumour cells vs | although trail/apo2l preferably induces apoptosis in .
The subject matter of this book was based on post-graduate lectures given to research workers, senior students in biochemistry, chemistry, medicine, veterinary science and agriculture at university college, london, in 1948 and 1949. In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data selective toxicity of antitumor drugs has been . Selective toxicity may be a function of a specific receptor required for drug attachment, or it may depend on the inhibition of biochemical events essential to the pathogen but not to the host the mechanisms of action of antimicrobial drugs can be discussed under four headings:. Cancer chemotherapy can be curative even in metastatic disease selective toxicity cancers that are rapidly dividing are most vulnerable to chemotherapeutic .
Selective toxicity in antibiotics synthetic antibiotic chemotherapy as a science and development of antibacterials began in germany with paul ehrlich in the late 1880s ehrlich noted that certain dyes would color human, animal, or bacterial cells, while others did not. 1 1 chapter 12 the elements of chemotherapy topics - antimicrobial therapy - selective toxicity - survey of antimicrobial drug - microbial drug resistance. Study flashcards on selective toxicity and principles of chemotherapy at cramcom quickly memorize the terms, phrases and much more cramcom makes it easy to get the grade you want. This report will focus on principles and challenges of selective toxicity of chemotherapy, how they work, the limitations of the current chemotherapy and ways to improve drugs mechanism of action chemotherapy drugs are able to move throughout the body to get to where they are intended by entering the bloodstream through an injection, a drip .
Due to this ground selective toxicity is a preferable chemotherapy for the intervention of malignant neoplastic disease selective toxicity may be achieved through inventing drug regimens based on pharmacokinetic informations ( zubrod, 1978 ) . In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data selective toxicity of antitumor drugs has been demonstrated for rapidly growing large growth fraction tumors occurring in patients under age 30 in these . B) selective toxicity takes advantage of structural and/or metabolic differences between host and pathogen c) selective toxicity takes advantage of metabolic differences between host and pathogen d) antimicrobial agents must target structural differences between host and pathogen and be more toxic to the patient than the pathogen.
Trends in microbiology, international arabic journal of antimicrobial agents, journal of antimicrobial chemotherapy, selective toxicity . Basic principles of antimicrobial therapy • chemotherapy = the use of chemicals against • selective toxicity = the ability of a drug to injure a. Selective toxicity is the underlying principle supporting ehrlich's idea of the magic bullet this simply means that the most effective antimicrobial drugs are . 7 antimicrobial chemotherapy terminology antibiotics, antiviral, antifungal, antimicrobial properties of antibiotics selective toxicity,therapeutic index, spectrum of activity.